From a Toxin to a Medicine – The Amazing Story of Botox
Botox, Dysport and recently Xeomin all belong to the same family of medications derived from botulinum toxin, a naturally-occurring protein produced by specific bacteria. When injected carefully into muscles, they are capable of blocking the transmission of signals from the nerve terminals into the muscles, preventing muscle contraction in a controlled and reversible way.
Thanks to their unique and specific mode of action, these medications have found their way in treatment of a growing list of medical conditions. Here are a few examples: migraine headaches, muscle spasms in neck and other areas (including spasm in patients with Multiple Sclerosis), cervical dystonia, excessive sweating (Hyperhidrosis), painful TMJ (temporo-mandibular joint), anal fissures, overactive bladder (urinary incontinence), Bell’s palsy, tennis elbow, crossed (lazy) eyes (squint or strabismus), essential tremor, eye twitching, blepharospasm and more. What all these very different conditions share is overactive or abnormally-strong contraction of muscles, which results in pain and/or interferes with normal function of the organ. By relaxing the involved muscles, Botox, Dysport and Xeomin alleviate the symptoms.
Cosmetic Uses of Botox, Dysport and Xeomin
Botox, Dysport and Xeomin are also widely used for medical cosmetic treatments. Upon injection into facial muscles, these medications can reduce or eliminate the appearance of lines and wrinkles through relaxing and weakening the underlying muscles that are responsible for contracting the skin and causing those folds. Botox, Dysport and Xeomin are most effective against “dynamic” lines and wrinkles – those that diminish when the muscle relaxes. But if left untreated, these “dynamic” wrinkles can turn into “static” lines and become permanent. This issue underscores the importance of timely preventive treatment with Botox, Dysport or Xeomin before the dynamic lines become static and permanent. When done skillfully, the natural facial expressions are preserved and only the excessive contractions that are responsible for wrinkles and lines are controlled.
The cosmetic uses of Botox and other medications in this family are not limited to eliminating lines and wrinkles. Another use of these medications is for jaw line reduction and facial slimming. When injected carefully into prominent jaw muscles, they can relax the hypertrophic jaw muscles and confer a slimmer and more shapely jaw and lower face. Similarly, Botox and other similar medications can be used to reduce the bulk of calf muscles, for slimmer lower legs (calf slimming).
Jaw Slimming Using Botox Injections
Injection of Botox and other similar medications, Dysport and Xeomin is an important and often irreplaceable part of a comprehensive rejuvenation treatment, alongside with injection of fillers such as Juvederm, Perlane, Restylane, Radiesse, Belotero, Sculptra and Voluma. Use combined, these medications can reverse years of aging with minimal discomfort, a procedure known as liquid facelift.
Which One Is Better – Botox, Dysport or Xeomin?
For years, Botox was the only available medication in the family of neurotoxins which resulted in its wider brand recognition. The family has recently become larger with addition of two new members, Dysport and Xeomin. All these medications are derived from botulinum toxin, a naturally-occurring protein produced by specific bacteria. When injected carefully into muscles, they are capable of blocking the transmission of signals from the nerve terminals into the muscles, preventing muscle contraction in a controlled and reversible way. They are used in a number of cosmetic applications, including reduction of facial wrinkles and lines such as crow’s feet, frown lines, and forehead lines, as well as reducing the tone and bulk of muscles for aesthetic reasons (e.g. jaw slimming and calf slimming). The wrinkle-reducing effect typically lasts for 3-6 months for all 3 types of medication. As it is often discussed that Botox, Dysport and Xeomin are all supposed to do the same thing, these questions come to mind of many:
– What is the difference between Botox, Dysport and Xeomin?
– Which one of these medications work better for me?
In the US, Botox was approved by FDA in 1989, while the approval of Dysport and Xeomin came on 2009 and 2011, respectively. Manufactured by different pharmaceuticals, these medications each have distinct concentration and composition, even though they share similar active agent – botulinum toxin type A. In comparison with Botox and Dysport, Xeomin acts more similarly to Botox than Dysport. Here is a summary of some of the differences between Botox, Dysport and Xeomin:
From a structural point of view, Xeomin is highly purified with little or no other additive proteins, while Botox and Dysport contain other accessory proteins. These accessory proteins make the active agent in Botox the largest and heaviest of all there, followed by Dysport. While the clinical effects of these differences are still debated, they may be the underlying causes of some of the other differences discussed below.
Presence of more additive proteins may increase the risk of allergic reactions and emergence of neutralizing antibodies which may eventually block the effect of Botox or Dysport (Botox/Dysport resistance). The risk of resistance is likely to be less for Xeomin.
The time it takes for Dysport to kick in may be slightly faster than Botox and Xeomin (typically within 4 days for Dysport versus within one week for Botox and Xeomin).
Generally speaking, 20 units of Botox or Xeomin provide potency similar to 50 units of Dysport. This is because these medications have been formulated by their manufacturer to have different concentrations when reconstituted for injection. However, the cost per unit of each medication is also proportional to the potency, and hence the total regular cost of treatment with either Botox, Dysport or Xeomin for any given area or condition should be very close.
Upon injection, the local diffusion and spread of medication into adjacent tissues is usually in this order: Xeomin > Dysport > Botox. This can be a potential positive or negative depending on the condition that is being treated: For issues such as crow’s feet or injections around eyes where a multitude of muscles are present and function, a more focused and localized-acting agent is often desired to avoid affecting other muscles nearby, and this can be best achieved with Botox. In other areas where larger muscles are acting, more spreading of the medication may actually help with more uniform results, and in these cases Dysport or Xeomin may have the edge. The issue of different diffusion is important when “converting” between Botox, Xeomin and Dysport units, as doses which are expected to have similar potency may still behave differently due to their different spread into the tissues. In all cases, your physician can make recommendations upon careful examination of your face and conditions that are being addressed.
And last, the most controversial issue: In terms of effectiveness and longer-lasting results, which product is better? There are many anecdotal reports and a number of studies addressing this, but the jury is still out. In a study published in 2011 (Nettar et al, Arch Facial Plast Surg) in which patients received Botox in one-half of their face and Dysport in the other half (with the patients not knowing which side got which medication), patients tended to see better results with Dysport. One caveat was the manufacturer of Dysport agreed to provide financial support to the study but the manufacturer of Botox declined, creating a potential conflict of interest. Another study in 2012 (de Morais et al. J Drugs Derm) concluded that there was no significant difference between Botox, Dysport and Xeomin, but this study was performed on a very small number of participants, negatively affecting the reliability of the results. Finally, in an independent study published in 2013 (Kassir et al. Dermatol Ther), Dysport results appeared faster and lasted longer.
While some evidence may support somewhat better response to Dysport compared with Botox, this should be viewed in light of other important differences between these medications discussed here. The conversion of Botox to Dysport units (often assumed around 1 unit Botox = 2.5 units Dysport) is somewhat tricky and may not be very accurate while some studies may use other conversions. As such, a number of expert panels have concluded that the available scientific evidence cannot support superiority of Dysport over Botox or vice versa yet, and more studies are still needed.
Perhaps the most important thing to remember when it comes to Botox, Dysport and Xeomin is that the ultimate issue is how body interacts with them, and our bodies being different from each other, the individual response of patients may be very different. The only thing that can be said with certainty is that some patients may respond better to one or another medication in this family, while some other may show similar results. To make the matter more confusing, the same patient may respond better to one medication now, but that changes as time passes with the patient ending up responding better to another medication. Your doctor often can exploit this fluid nature of response to your benefit: For patients who may see a decline in response to one type of medication, say Botox, over time, your doctor may recommend you to switch to Dysport or Xeomin to see if you can get better results.
To further explore your treatment options using Botox, Dysport or Xeomin and other injectable cosmetic medications for comprehensive rejuvenation, contact our clinic and schedule your complimentary consultation with Dr. Jafari – the top doctor for Botox (Allergan Platinum-level provider), Dysport and Xeomin in Irvine, Newport Beach and Orange County today!
Amoderm is pleased to offer Botox, Dysport and Xeomin for patients throughout Orange County as well as patients from Los Angeles, San Diego, Riverside and San Bernardino Counties. The patients we serve come from cities near and far, including Aliso Viejo, Anaheim, Costa Mesa, Cypress, Dana Point, Foothill Ranch, Fountain Valley, Fullerton, Garden Grove, Huntington Beach, Irvine, Ladera Ranch, Laguna Beach, Laguna Hills, Laguna Niguel, Laguna Woods, Lake Forest, Mission Viejo, Newport Beach, Newport Coast, Orange, Placentia, Rancho Santa Margarita, San Clemente, San Juan Capistrano, Santa Ana, Tustin, Westminster, Yorba Linda and more.
DISCLAIMER: Every patient is different. Individual results may vary and no guarantee can be made. We will discuss your treatment(s), expected results, possible risks, costs and alternative options with you during your visit.
NOTICE TO CONSUMERS: Medical doctors are licensed and regulated by the Medical Board of California. (800) 633-2322 - www.mbc.ca.gov
Amoderm Cosmetic and Wellness Medical Center in Irvine is your one-stop clinic for a healthier & rejuvenated look. Visit us for Botox, Dysport, Xeomin, Kybella, Juvederm, Radiesse, Restylane, Perlane, Belotero Balance, Bellafill, Juvederm Voluma, Juvederm Volbella, Sculptra, Chemical peels, Microlaser peel, Laser skin resurfacing, Fractional CO2 laser skin resurfacing, IPL Photofacial, Skin tightening, Body sculpting, Cellulite reduction, Radiofrequency treatments, SculpSure fat reduction and body contouring treatments, Venus Freeze, Microdermabrasion, Laser hair removal, Stretch mark removal, Spider vein removal, PDO Threadlift, Toenail fungus laser treatment, Facials, Latisse & more!
Visit Amoderm Cosmetic & Wellness Center, Medspa & Skin Care Clinic today for a healthier & younger you! Conveniently located in heart of Irvine & easily accessible from Orange County major freeways, Amoderm is proud to provide cutting-edge cosmetic & wellness services & premium skin care products designed to provide antiaging, anti-acne, sun protection & other functions vital to healthy & youthful skin. Under direct supervision of Dr. Elham Jafari, MD, a California-licensed, board-certified physician & an experienced aesthetic medicine specialist, Amoderm Medspa is pleased to offer an expansive list of professional medical cosmetic services including Botox, Dysport, Xeomin, Kybella, Juvederm, Radiesse, Restylane, Perlane, Belotero, Voluma, Volbella, Bellafill and Scluptra all injected skillfully by licensed physician and used individually or in combination for liquid facelift. Whenever indicated, we inject fillers using flexible Microcannula (micro-cannula) for better results, less pain and less bruising. Amoderm also offers various customized chemical skin peels, VI peel, Microlaser peel (laser skin resurfacing), IPL (Photofacial), skin tightening using laser and radiofrequency, Microdermabrasion, PDO Threadlift, Laser hair removal, Stretch mark removal, Laser vein removal, Spider vein removal, Toenail fungus laser treatment, Venus Freeze, SculpSure Latisse, and anti-aging skin care products. Call us today to schedule your free consultation!
At Amoderm Cosmetic & Wellness Clinic, our goal is to create a healthy, natural and age-defying look. Our focus is on whole-face rejuvenation using a combination of fillers, neurotoxins (Botox, Dysport, Xeomin) and various laser and radiofrequency treatment. We offer various medical cosmetic treatments to enhance and accentuate your natural beauty. At Amoderm, we explore all options to rejuvenate, slow down and reverse the aging process using the most advanced, clinically-proven, affordable and safe treatments that are customized to your specific conditions and needs. It's all about you, and what is right for you. The good news is that many things can be done to effectively reverse the aging process without expensive surgeries and alike. Our patients often find it hard to believe what can be achieved in a single visit using a carefully selected combination of botox, dysport and filler injections and lasers. Our emphasis is on whole-face rejuvenation with natural-looking results. Often, years of aging can be undone in just a few minutes.
It's very important for us to have a face-to-face discussion with you to know you better; where you are coming from; what issues you want to address; what your expectations are; and how we can help you best. We also want you to know us better to make sure Amoderm is the right place for you. That's why we always offer complimentary consultations to our patients. When you come to Amoderm, you can be assured that you will be treated with utmost courtesy, honesty and professionalism. We truly care about you, your comfort and your well-being. We know that going to a cosmetic clinic is not necessarily the most pleasant experience, but we do whatever it takes to make it as pleasant and as stress-free, and as comfortable as possible for you. Our services include:
- Botox, Dysport & Xeomin injections to wipe out dynamic wrinkles and more. Botox, Xeomin & Dysport are effective in reducing and removing wrinkles and fine lines. Additionally, Botox is FDA-approved for treatment of other conditions such as excessive sweating (hyperhidrosis), muscle stiffness (spasticity) and migraine headaches, which are also provided at Amoderm. Other cosmetic treatments we provide using Botox, Dysport and Xeomin include jaw slimming and jaw line reshaping, calf slimming, nose reshaping, eyebrow lift, treatment of neck (platisma) bands and more. Say goodbye to the wrinkles, fine lines, crows’ feet, frown lines, worry lines & forehead creases by Botox & Dysport injections & take years away from your face!
- Filler injections (Juvederm, Radiesse, Sculptra, Belotero, Voluma, Volbella, Bellafill, Restylane & Perlane) to add volume & diminish wrinkles instantly. Dermal fillers are used to create volume under the skin in a fine & skillful procedure that has been likened to sculpting or non-surgical face lift. Dr. Jafari is highly experienced in using various dermal fillers such as Juvederm, Radiesse, Sculptra, Belotero, Restylane & Perlane to accentuate your natural beauty & defy the effects of aging. Juvederm, Belotero, Voluma, Restylane & Perlane are based on hyaluronic acid, a gel-like substance that is naturally present in skin, contributing to the firmness of young & healthy skin. Dr. Jafari at Amoderm Med Spa can replenish the skin’s lost hyaluronic acid by injection of Juvederm, Perlane, Restylane, Belotero or Voluma. On the other hand, Radiesse utilizes a calcium-based microsphere technology, which not only provides immediate volume restoration, but it also stimulates the body to produce new collagen, creating much more long-lasting results. Similarly, Sculptra is derived from corn-starch and is highly effective in stimulating body to produce more collagen. Dr. Jafari skillfully injects the dermal fillers into areas such as smile lines, nasolabial folds, marionette lines, lips, tear trough, nose bridge, cheeks, chin, neck and hands and takes away years of age in a few minutes! Dr. Jafari is highly experienced in techniques such as microcannula injections, which can reduce the bruising associated with the procedure.
- Medical-Grade Customized Chemical Peel including VI Peel and Obagi Blue Peel to create vibrant, healthy, and rejuvenated skin.
- MicroLaser peel (Laser skin resurfacing) to rejuvenate the skin, for active acne and acne scar, stretch marks, pigmentation, skin sun damage, scars, and wrinkles.
- Fractional CO2 laser resurfacing for deeper laser peels resulting in more effective skin rejuvenation.
- IPL (Photofacial) to stimulate collagen and treat vascular lesions, sun damage, pigmentation, open pores, acne and redness.
- Micro-needling (Microneedling, dermapen, dermaroller) to stimulate collagen, treat superficial scars and improve skin tone and texture.
- Skin tightening to stimulate collagen, increased skin tone and tightness.
- Laser spider vein removal to remove unsightly superficial veins such as the spider veins.
- Medical-grade crystal-free diamond Microdermabrasion to treat superficial hyperpigmentation, photodamage, and fine lines.
- Laser hair removal for a silky-smooth, vibrant and maintenance-free skin.
- Stretch mark removal to effectively reduce the appearance of stubborn striae and stretch marks.
- Toenail fungus Laser treatment to safely, effectively and permanently treat toenail fungus.
- Radiofrequency and Venus Freeze treatments for body contouring, skin tightening, wrinkle reduction, cellulite treatment and size reduction.
- Platelet-rich Plasma (PRP) to rejuvenate face using body's own growth factors (optionally combined with fillers).
- Signature Facials to promote your natural beauty and the health of your skin.
- Wellness program for better health, better management of chronic diseases and weigh adjustment.
- Latisse for fuller beautiful eyelashes
Amoderm Medical Spa is located in Irvine, California. We proudly serve clients from all cities & neighborhoods in the OC including Aliso Viejo, Anaheim, Anaheim Hills, Capistrano Beach, Corona Del Mar, Costa Mesa, Coto De Caza, Crystal Cove, Cypress, Dana Point, Fashion Island, Foothill Ranch, Fountain Valley, Fullerton, Garden Grove, Huntington Beach, Irvine, Ladera Ranch, Laguna Beach, Laguna Hills, Laguna Niguel, Laguna Woods, Lake Forest, Mission Viejo, Newport Beach, Newport Coast, Orange, Pelican Hills, Placentia, Rancho Santa Margarita, San Clemente, San Juan Capistrano, Santa Ana, South Coast Plaza, Surfside, Tustin, Tustin Legacy, Tustin Ranch, UCI, University Park, Westminster, & Yorba Linda. In addition to the cities in the Orange County, Amoderm Medspa often provide services to clients from other counties including Los Angeles, San Diego, Riverside & San Bernardino & other cities and counties in Southern California.